Molecular self-assembly serves as a powerful strategy for developing complex systems with extraordinary biological functions, particularly in the realm of biological sensing and imaging applications. Our research focuses on harnessing the inherent properties of DNA and peptides, components of nature's toolkit, to engineer intelligent nanodevices. By capitalizing on the self-assembly capabilities of these biomolecules, we strive to fabricate intricately designed structures that exhibit exceptional specificity and dynamic behavior. These structures enable us to create novel sensing and imaging platforms that can accurately detect and visualize biological targets with high precision and sensitivity. Our work aims to revolutionize the field of biological diagnostics by providing innovative tools for understanding and monitoring biological processes at different levels of bioorganization.
Plasmonic nanoantennas
Signal amplification strategies are pivotal in improving the sensitivity, speed, and reliability of point-of-care diagnostic assays. Our groundbreaking approach involves harnessing the power of plasmonic nanostructures as optical nanoantennas, capable of concentrating excitation light into zeptoliter volumes. By leveraging this technology, we achieve remarkable enhancements in optical signals from both fluorophores and Raman-active molecules. With our cutting-edge plasmonic nanoantennas, we are revolutionizing the field of sensing assays, paving the way for highly sensitive and efficient point-of-care diagnostics.
Self-assembly
Molecular self-assembly, a fascinating process in biology, involves the spontaneous organization of molecules into complex structures. It plays a crucial role in various biological phenomena, including protein folding, DNA replication, and cell membrane formation. Harnessing the principles of molecular self-assembly opens new possibilities for creating novel optical imaging nanodevices. Leveraging molecular self-assembly, we unlock innovative approaches for developing advanced optical imaging technologies with enhanced sensitivity and resolution.
Molecular and cellular imaging
Targeted imaging of cancer cells and their cellular functions provides invaluable insights into the complex nature of cancer biology. By employing specialized molecular probes, this advanced imaging technique enables precise visualization and analysis of specific molecular targets within cancer cells, shedding light on their behavior and interactions. We are dedicated to pushing the boundaries of targeted cancer imaging by developing innovative nanobiosensors that enhance sensitivity, accuracy, and real-time monitoring of cellular processes, facilitating advancements in cancer research and personalized treatment approaches.